What remark made by a patient with a transdermal patch indicates a need for further investigation?

The remark about experiencing itching and burning from the transdermal patch indicates a need for further investigation because these symptoms may suggest an allergic reaction or irritation at the application site. Itching and burning are not typical side effects of a properly placed transdermal patch; therefore, they could signal that the patient is having an adverse reaction to the medication or the adhesive itself. This warrants a discussion with the healthcare provider to assess the reaction, examine the application technique, and consider alternative medications or patches that may be more suitable for the patient.

The other remarks, while they may indicate other considerations or patient experiences, do not necessitate immediate further investigation in the same way that the itching and burning do. Issues related to the number of patches, the realization about body hair, and concerns about the patch's adherence could be related to normal patient experiences with transdermal therapies, but they do not raise immediate concerns regarding the patient's health or safety.